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gw7647 cayman  (Cayman Chemical)

 
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    Cayman Chemical gw7647 cayman
    V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist <t>GW7647</t> (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.
    Gw7647 Cayman, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/gw7647 cayman/product/Cayman Chemical
    Average 90 stars, based on 1 article reviews
    gw7647 cayman - by Bioz Stars, 2026-03
    90/100 stars

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    1) Product Images from "PPARɑ variant V227A reduces plasma triglycerides through enhanced lipoprotein lipolysis"

    Article Title: PPARɑ variant V227A reduces plasma triglycerides through enhanced lipoprotein lipolysis

    Journal: Journal of Lipid Research

    doi: 10.1016/j.jlr.2025.100806

    V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist GW7647 (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.
    Figure Legend Snippet: V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist GW7647 (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.

    Techniques Used: Quantitative RT-PCR, Western Blot, Gene Expression, Binding Assay, ChIP-qPCR



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    V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist <t>GW7647</t> (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.
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    gw7647 cat# 1677  (Tocris)
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    V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist <t>GW7647</t> (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.
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    Image Search Results


    V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist GW7647 (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.

    Journal: Journal of Lipid Research

    Article Title: PPARɑ variant V227A reduces plasma triglycerides through enhanced lipoprotein lipolysis

    doi: 10.1016/j.jlr.2025.100806

    Figure Lengend Snippet: V227A increases Lpl transcript abundance in liver. A: Genes that account for GSEA enrichment of lipoprotein catabolism gene set used in I. B: qRT-PCR of PPARɑ target genes using liver tissue from 6-h fasted chow-fed male (n = 11–15 per group), chow-fed female (n = 12 per group), Western diet-fed male (n = 10–11 per group), and Western diet-fed female mice (n = 6–8 per group). C: Lpl transcript abundance in liver tissue from male mice with indicated fasting duration as assessed by qRT-PCR (n = 4–9 per group). D: Gene expression in liver tissue from 6-h fasted male mice gavaged with PPARɑ agonist GW7647 (10 mg/kg) as assessed by qRT-PCR (n = 8). E: Ppara binding to Lpl enhancer (Enh) and promoter genomic regions in 6-h fasted V227A liver tissue (n = 5) as assessed by ChIP-qPCR. Enrichment is normalized to Rpl35 promoter region that does not exhibit known PPARɑ binding . ∗ = P < 0.05, ∗∗ = P < 0.01, ∗∗∗ = P < 0.001 as assessed by Student’s t test. Error bars are SEM.

    Article Snippet: GW7647 (Cayman) was prepared in 0.5% hypromellose and gavaged at 16 and 21 h prior to tissue harvest.

    Techniques: Quantitative RT-PCR, Western Blot, Gene Expression, Binding Assay, ChIP-qPCR